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Background Efficacy in previous studies of surgical treatments of refractory multiple sclerosis tremor using lesioning or deep brain stimulation (DBS) has been variable. The aim of this study was to investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius–ventralis oralis posterior nucleus border [the VIM lead] and one targeting the ventralis oralis anterior–ventralis oralis posterior border [the VO lead]) for the treatment of multiple sclerosis tremor. Methods We did a single centre, single-blind, prospective, randomised pilot trial at the University of Florida Center for Movement Disorders and Neurorestoration clinic (Gainesville, FL, USA). We recruited adult patients with a clinical diagnosis of multiple sclerosis tremor refractory to previous medical therapy. Before surgery to implant both leads, we randomly assigned patients (1:1) to receive 3 months of optimised single-lead DBS—either VIM or VO. We did the randomisation with a computer-generated sequence, using three blocks of four patients, and independent members of the Center did the assignment.

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Sheldon D Sheldon D. Pollack Professor of Law, Legal Studies & Political Science University of Delaware Newark, DE 19716 Office: Purnell 216 (302) 831-1803 tel. (302) 831-4676 fax email: Education J.D. University of Pennsylvania Law School (1986) Ph.D. Cornell University, Department of Government (1980) B.A.

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